EARLY DETECTION OF VERRUCOUS CARCINOMA USING METHYLENE BLUE STAINING IN SUSPECTED LEUKOPLAKIA LESION: A CASE REPORT

Introduction: Verrucous carcinoma is one of squamous cell in the oral cavity which can caused by smoking, alcohol consumption, HPV etc. mimick as pre cancer lesion such leukoplakia, so that early detection mandatory. Vital staining be done toluidine blue, but it reported toxic organ. Methylene blue had similar chemical structure and exhibited physicochemical properties to blue.The aim this case report verrucous using methylene leukoplakia among smoker alcoholic patient. Case: A 46-year-old male patient came RSIGM Sultan Agung Semarang complaint there was a wound on left cheek has not healed for last 3 years. The painful sore when exposed food. been treated Albothyl no change. an active since 20 years ago consume much 2-3 packs cigarettes/day also consumed about 4 ago. Intraoral examination nodular white plaques, unscrappable with pigmentation areas painless. Clinical diagnosis leukoplakia. Case Treatment: Early 1% obtained positive dark indicated change malignancy. Patients were given symptomatic therapy triamcinolone acetonide orabase 0.1% then excisional biopsy performed histopathological appearance shows thickening changes polarity epithelial cells dysplasia. final carcinoma. Conclusion: persistent plaque risk factors smoking suspicion toward malignancy, before biopsy.